Needle-Free Testosterone
Oral TRT (Kyzatrex®)
Kyzatrex® (testosterone undecanoate) is an FDA-approved oral testosterone capsule taken twice a day with food. Unlike older oral testosterones, it bypasses the liver via the lymphatic system — so it can deliver clinically meaningful testosterone levels safely, without the hepatic risks that plagued first-generation oral T.
How it works
The mechanism
Each capsule contains testosterone undecanoate, a fat-soluble ester. Taken with a meal, it's absorbed into the lymphatic system rather than the portal vein, sidestepping first-pass liver metabolism. The ester is then cleaved in circulation, releasing free testosterone. Stable physiologic levels are achieved with twice-daily dosing.
Who it's for
Best candidates
- Men who refuse or can't self-inject
- Patients with needle-related anxiety
- Frequent travelers who want simple compliance
- Men whose lab profile and meal pattern are compatible
Protocol
Starting dose is typically 200 mg twice daily with food. Bloodwork drawn 4–6 hours after the morning dose at week 6. Adjustments made in increments based on free T and symptoms.
Timeline
Most men feel libido and energy improvements within 4–6 weeks. Body composition and strength changes follow over 3–6 months.
What to expect
Side effects & considerations
Possible blood-pressure rise (we monitor at every visit), mild GI upset, headache. Standard TRT-related considerations apply (hematocrit, estradiol).
Frequently asked
Oral TRT (Kyzatrex®) FAQs
Pairs well with
Related treatments
Steady Support
Testosterone Cypionate Injections
The gold-standard injectable testosterone for stable, predictable hormone levels.
3–5 Months of Steady T
Testosterone Pellets
Bio-identical testosterone implants that deliver months of stable hormone levels — no weekly injections.
Fertility-Sparing TRT
Clomid & Enclomiphene
Oral medication that stimulates your own testosterone production — no injections, no shut-down.
Take the first step
Feel like yourself again — book a free consult.
15 minutes. No pressure. A clear plan if you want one.